Synthetic lethality strategy γ☆÷"allows us to cure cancers wit •↓h mutations on tumor suppr↑≤essor genes. In particular, weγ≠ are able to indirectly tε★π♣arget those “undruggable★ δ” tumor suppressors to drasticall'π¥ y expand the scope of cancer ther✘®α"apeutics. In combination •γwith other types of cancer t&≠herapies, such as tumor immuno÷₽ therapy, our approach also has the♠♣ ↕ potential to overcome cancer d×≤rug resistance caused by secondary$‌ mutations arising from c£Ω£∑onventional cancer therapies. In sφ→ hort, synthetic lethality strategie★βs specifically kill canc÷↓er cells with a clear biomarker ÷βΩand create a clear pathway for c®δφancer treatment.